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Amoxicillin vs ampicillin for acne and inflammatory acne, of the 3 amoxicillin combinations, 1.66 vs. 1.28 (CI 95%: CI. 95%; CI 95%), although most trials with amoxicillin did not have a significant result (OR 0.46; CI 0.25–0.95). In the study by Sareen et al. (2012) (12), the proportion of patients treated with a single antibiotic showed that, while amoxicillin was not superior to azithromycin (OR 0.96; CI 95%: CI0.81–1.14), it made a very good second choice (OR 0.84; CI 0.64–1.11). On the other hand, OR for combination of 2 antibiotics was, without any heterogeneity, 0.80 (CI 95%: CI 0.45–1.37). The results for oral tetracyclines may not be so robust: their combination in patients with IBD failed to show a statistically significant outcome; (p = 0.05) reduction in mean IBD lesional area was demonstrated only for erythromycin, clindamycin, mebendazole and clindamycin plus gentamicin; although most antibiotics are not always effective when administered twice in the same time window (Langherin et al. 2001). The results for anorexia nervosa are less clear, if the studies in question are compared together. a study by Fiehler et al. (2008) (7), most of the included studies did not have significant results; the ORs reported ranged from 1.16 to 4.36 (CI 95%: CI 0.89–2.80). Among them, the combination of metronidazole vs quinolone did show a beneficial effect, as well the combined treatment of sulfonamides and terramycin, which indicated a strong effect on IBD (OR 1.34; CI 95%:CI 1.07–1.75, respectively). A number of the included studies reported significant results for combination therapy of sulfonamides (OR = 1.29; CI 95%:CI 1.14–1.47, and penicillin vs ampicillin vs amoxicillin OR = 2.49; CI 95%: 1.38–4.04); 2 other studies showed that metronidazole was not superior to either of the other 2 agents and were not included in this analysis (Española-Radego et al. 2008; Gómez-Reverio 2010). Although Gorgels et al. (2013) (31) also made no significant finding, in their study, the combination of azithromycin and azathioprine was superior to either for IBD-specific outcome (OR severe disease, 1.28; CI 95%:CI 1.05–1.54), whereas the combination of both them was significantly better in terms of no-articular disease (OR for severe 0.55; CI 95%:CI 0.36–0.76). Other positive combinations of these antibiotics were seen in one (Jensen and Aase 1996:24), another (Mannink et al. 2006) and an additional one (Azevedo et al. 2006) of the included studies in our meta-analysis. The latter study also showed that the combination of metronidazole plus amoxicillin improved IBD outcomes in patients with IBD-specific disease (OR drug store skin care brands 1.37; 95:CI 1.08–1.74). Another study (Luo et al. 2009) showed that the combination of sulfonamides with daptomycin provided a slight survival benefit with respect to all other treatment regimens. The combination of 2 antibiotics could be useful and appropriate in the IBD-associated skin disease (Kirkland et al. 2014a; Kirkland 2014b). In that study, the efficacy for IBD-associated eczema was comparable to that of oral corticosteroids and metronidazole, but this result had not been demonstrated for Crohn's disease (CRL; p = 0.18). Finally, for dermatitis, a single regimen of azithromycin plus metronidazole was the first-choice option for about 95% of the patients (Carretero et al. 2014) and the second choice was oral azithromycin alone, for the 7% patients with IBD-specific disease. For acne, some studies reported significantly superior (e.g., Waisman et al. 2008; Pichai 2011) and at least partial (e.g., Cunha et al. 2013) results for azithromycin alone, which Ventolin over the counter canada is very good evidence for its superiority to other drugs. Most studies reported that combination therapy with several antibiotics is preferable to metronidazole alone decrease the frequency of.

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